Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta

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Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta

Objective To explore the relationship between cellular apoptosis and hypertrophy of the ligamentum flavum in the lumbar region. Methods Thirty patients with lumbar spinal stenosis were evaluated. Hypertrophy of the ligamentum flavum was present in 15 patients and absent in 15. Hematoxylin-eosin staining and transforming growth factor beta (TGF-β) immunohistochemical testing were applied to comp...

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Ossification and hypertrophy of ligamentum flavum at thoracic spine.

BACKGROUND Hypertrophy of the ligamentum flavum is a pathological condition that causes neurological symptom (radiculopathy and / or myelopathy) and usually occurs in the thoracic,2 less frequently in the cervical spine that commonly involves thoracic spine. This study was conducted to analyse the clinical presentation and outcome of surgery of ossified ligamentum flavum at thoracic spine. ME...

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  Background and Objectives: Nasal polyposis is a diseases resulting from complex pathogenetic mechanisms. Some studies showed that TGFβ1 had significant role in this pathogenesis. In this study, we investigated the roe of cytokines and mediators in polyp development. Material and Methods: In this case- control study, healthy nasal mucosal samples were obtained from 24 peopl...

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Experimental Mouse Model of Lumbar Ligamentum Flavum Hypertrophy

Lumbar spinal canal stenosis (LSCS) is one of the most common spinal disorders in elderly people, with the number of LSCS patients increasing due to the aging of the population. The ligamentum flavum (LF) is a spinal ligament located in the interior of the vertebral canal, and hypertrophy of the LF, which causes the direct compression of the nerve roots and/or cauda equine, is a major cause of ...

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ژورنال

عنوان ژورنال: Journal of International Medical Research

سال: 2017

ISSN: 0300-0605,1473-2300

DOI: 10.1177/0300060517711308